Omeprazole: Uses, Side Effects & Dosage Guide

Omeprazole is known as an oral anti-ulcer agent. Because of its characteristics of blocking the ending stage of gastric acid creation, it is categorized as a gastric acid pump inhibitor. It has an action of long duration and is actually effective, permitting for once-daily administration. Even with its effectiveness, this one is actually against helicobacter pylori and might be used in grouping with antibiotics.

Being concerned about long term use, it was accepted by FDA advisory committee and recommended it be allowed for upkeep therapy of cured erosive esophagitis. In April 1996, it was agreed for the cure of H.Pylori linked duodenal ulcer. It belongs to a novel class of antisecretory agents, switched benzimidazoles that suppress gastric acid discharge by obstructing the H+ /K+ ATPase pump that is on the secretory shallow of the parietal cell sheath. Subsequently, it impedes the discharge of hydrogen ions toward the gastric lumen. It impedes one basal and other stimulus-induced acid excretion. As a generic medication it is available.

Omeprazole is a good inhibitor of p-glycoprotein. Drugs that rely on an acidic environment of the stomach (such as ketoconazole or atazanavir) can be poorly absorbed, while to a greater extent acid-labile antibiotics may be absorbed than normal due to the alkaline stomach environment.

In 1978, Omeprazole was patented and in 1988, permitted for medical use. In World Health Organization’s it is in the List of Essential Medicines. In 2017, omeprazole was the seventh prescribed drug that most prescribe in the United State.

Indications

Omeprazole is primarily indicated in conditions like:

  • Acid reflux disease (long term management)
  • Duodenal ulcers and benign gastric 
  • Benign gastric ulcers allied with H.pylori
  • Benign duodenal ulcers allied with H.pylori
  • Gastric acid reduction through general anesthesia
  • Gastroesophageal reflux disease (refractory to other treatment)
  • Duodenal erosions
  • Upkeep of recurrent duodenal ulcers
  • Non-ulcer dyspepsia
  • NSAID-linked gastric duodenal ulcers
  • As a prophylaxis
  • In duodenal ulcers, prevention of relapse.
  • Prophylaxis of acid aspiration 
  • Zollinger-Ellison syndrome
  • Reflux oesophagitis
  • As an alternate drug of excellence in acid aspiration GI bleeding and syndrome prevention.

Contraindications

  • Vitamin B12 Deficiency
  • Liver Diseases
  • The lupus erythematosus(subacute cutaneous)
  • SLE
  • Autoimmune diseases
  • A deficient amount of magnesium in the blood
  • Interstitial nephritis
  • Osteoporosis
  • CYP2C19 poor metabolizer
  • a broken bone
  • Clostridium difficile related diarrhea.

Side Effects

  • The critical or irreparable acute effects of omeprazole that give rise to supplementary complications, including interstitial nephritis.
  • Omeprazole produces potentially life-threatening effects with anaphylaxis which is in charge of interruption of omeprazole therapy.
  • After the acute overdose of omeprazole symptoms and signs that are produced, comprise tachycardia, headache and drowsiness.
  • The symptomatic adversarial reactions created by omeprazole are nearly tolerable or if they turn out to be severe, they can be cured symptomatically, these take account of Dizziness, Flatulence, Fatigue, Nausea, Dry mouth,  Diarrhea, Myalgia, Headache,  Constipation, Insomnia, Urticarial, pruritus, Photosensitivity, Skin rash, Impotence, abdominal pain and Agitation.

Warnings

  • Patients with Kidney and liver disease must use omeprazole with care.
  • Avoid its use during lactation.
  • During pregnancy, take it when distinctly needed

High Risk Groups

  • Patients identified with hypersensitivity.
  • Predictable case of Liver and kidney failure